4-Calculator -Series-Renal & Electrolytes

Renal and electrolytes 

Series-Renal & Electrolytes Subcategory

1- Creatinine Clearance

Creatinine Clearance ( Cockcroft-Gault)--

Age (years): Weight (kg): Serum Creatinine (mg/dL):
Sex: Male Female

   ​Formula used:   $$CrCl = \frac{(140 - \text{age}) \times \text{weight (kg)}}{72 \times \text{Scr (mg/dL)}} \times (0.85 \; \text{if female})$$

Information-

Creatinine Clearance (CrCl), estimated using the Cockcroft-Gault equation, is a measure of renal function. Glomerular Filtration Rate (GFR) is calculated based on serum creatinine, age, weight, and sex. The assessment is key in detecting renal impairment and for dosage adjustment, particularly in patients with reduced renal function.

Cockcroft- Gault Calculation-

Creatinine Clearance (Cockcroft- Gault)

where Clcr=Creatinine Clearance (mL/min), gender = 1.04 { female }, 1.23 { male }, IBW = Ideal Body weight, kg, SCr = Serum Creatinine, μmol/L​

2- MDRD eGFR Calculator

MDRD eGFR Calculator

Serum Creatinine (mg/dL): Age (years): Sex: Male Female Race: Other Black

Formula:

$$eGFR = 175 \times (Scr)^{-1.154} \times (Age)^{-0.203} \times (0.742 \; \text{if female}) \times (1.212 \; \text{if Black})$$

Information--

The Modification of Diet in Renal Disease (MDRD) study equation is used to estimate glomerular filtration rate (eGFR), providing an assessment of renal function. It takes into account serum creatinine levels, age, sex, and race. The MDRD equation is particularly useful for detecting and categorising Chronic Kidney Disease (CKD) and for decision-making on medications that are cleared by the kidneys. It is widely used due to its accuracy in estimating eGFR, especially in patients with reduced renal function.

References--

Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999;130(6):461-70.

3-- Anion Gap Calculator

Anion Gap Calculator

Sodium (Na⁺, mmol/L):
Chloride (Cl⁻, mmol/L):
Bicarbonate (HCO₃⁻, mmol/L):

Formula used: Anion Gap = 𝑁 𝑎 + − ( 𝐶 𝑙 − + 𝐻 𝐶 𝑂 3 − ) Anion Gap=Na + −(Cl − +HCO 3 − ​ )

Information--

The Anion Gap is used to help diagnose the cause of metabolic acidosis. It is calculated by subtracting the sum of chloride and bicarbonate levels from the sum of sodium and potassium levels. Calculating the difference between the positively charged ions, sodium and potassium, and the negatively charged ions, chloride and bicarbonate, determines the presence of unmeasured anions in the blood. This is particularly valuable in guiding the diagnostic process towards identifying acid-base imbalances and ensuring that patients receive appropriate treatment for conditions contributing to metabolic acidosis.

Anion Gap Calculation-

Anion Gap (mmol/L) = (Sodium + Potassium) - (Chloride + Bicarbonate)

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